| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GLRX3 (1-335) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GLRX3 |
| Gene ID: |
10539 |
| Uniprot ID: |
GLRX3_HUMAN |
| Immunogen Region: |
1-335 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-335 of human GLRX3 (NP_001186797.1). |
| Immunogen Sequence: |
MAAGAAEAAVAAVEEVGSAG QFEELLRLKAKSLLVVHFWA PWAPQCAQMNEVMAELAKEL PQVSFVKLEAEGVPEVSEKY EISSVPTFLFFKNSQKIDRL DGAHAPELTKKVQRHASSGS FLPSANEHLKEDLNLRLKKL THAAPCMLFMKGTPQEPRCG FSKQMVEILHKHNIQFSSFD IFSDEEVRQGLKAYSSWPTY PQLYVSGELIGGLDIIKELE ASEELDTICPKAPKLEERL |
| Tissue Specificity | Expressed in heart, spleen, testis and, to a lower extent, in thymus and peripheral blood leukocytes. Weakly expressed in lung, placenta, colon and small intestine. |
| Function | Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates 2Fe-2S cluster insertion into a subset of cytosolic proteins. Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator. Required for hemoglobin maturation. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. |
| Protein Name | Glutaredoxin-3Pkc-Interacting Cousin Of ThioredoxinPicotPkc-Theta-Interacting ProteinPkcq-Interacting ProteinThioredoxin-Like Protein 2 |
| Database Links | Reactome: R-HSA-917937 |
| Cellular Localisation | CytoplasmCytosolCell CortexMyofibrilSarcomereZ LineUnder The Plasma MembraneAfter Pma StimulationGlrx3 And Prkcq/Pkc-Theta Translocate To A More Extended Submembrane AreaIn The Z LineFound Associated With Csrp3 |
| Alternative Antibody Names | Anti-Glutaredoxin-3 antibodyAnti-Pkc-Interacting Cousin Of Thioredoxin antibodyAnti-Picot antibodyAnti-Pkc-Theta-Interacting Protein antibodyAnti-Pkcq-Interacting Protein antibodyAnti-Thioredoxin-Like Protein 2 antibodyAnti-GLRX3 antibodyAnti-PICOT antibodyAnti-TXNL2 antibodyAnti-HUSSY-22 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
