| Post Translational Modifications | C-terminus cleavage is induced by interaction with CTNND1 and enhanced by Src tyrosine kinase. |
| Function | Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway. Represses the Hedgehog-dependent expression of Wnt4. Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition. Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation. |
| Protein Name | Zinc Finger Protein Glis2Gli-Similar 2Neuronal Krueppel-Like Protein |
| Cellular Localisation | Nucleus SpeckleCytoplasm |
| Alternative Antibody Names | Anti-Zinc Finger Protein Glis2 antibodyAnti-Gli-Similar 2 antibodyAnti-Neuronal Krueppel-Like Protein antibodyAnti-GLIS2 antibodyAnti-NKL antibody |
Information sourced from Uniprot.org
