Anti-GLB1 antibody (1-349) (STJ115624)

Name: Anti-GLB1 antibody (1-349) (STJ115624)
SKU: STJ115624
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ115624

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Short Description	Rabbit polyclonal GLB1 (1-349) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	GLB1
Gene ID	2720
Uniprot ID	BGAL_HUMAN
Immunogen Region	1-349
Immunogen Sequence	TSYDYDAPLSEAGDLTEKYF ALRNIIQKFEKVPEGPIPPS TPKFAYGKVTLEKLKTVGAA LDILCPSGPIKSLYPLTFIQ VKQHYGFVLYRTTLPQDCSN PAPLSSPLNGVHDRAYVAVD GIPQGVLERNNVITLNITGK AGATLDLLVENMGRVNYGAY INDFKGLVSNLTLSSNILTD WTIFPLDTEDAVCSHLGGWG HRDSGHHDEAWAHNSSNYTL PAFYMGNFSIPSGIPDLPQ
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human GLB1 (NP_000395.3).

Tissue Specificity	Detected in placenta (at protein level). Detected in fibroblasts and testis.
Function	Isoform 1: Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Isoform 2: Has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers.
Protein Name	Beta-Galactosidase Acid Beta-Galactosidase Lactase Elastin Receptor 1
Database Links	Reactome: R-HSA-2022857 Reactome: R-HSA-2024096 Reactome: R-HSA-2206308 Reactome: R-HSA-4085001 Reactome: R-HSA-4341670 Reactome: R-HSA-6798695 Reactome: R-HSA-9840310
Cellular Localisation	Isoform 1: Lysosome Isoform 2: Cytoplasm Perinuclear Region Localized To The Perinuclear Area Of The Cytoplasm But Not To Lysosomes
Alternative Antibody Names	Anti-Beta-Galactosidase antibody Anti-Acid Beta-Galactosidase antibody Anti-Lactase antibody Anti-Elastin Receptor 1 antibody Anti-GLB1 antibody Anti-ELNR1 antibody

Information sourced from Uniprot.org