| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GLB1 (1-349) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GLB1 |
| Gene ID: |
2720 |
| Uniprot ID: |
BGAL_HUMAN |
| Immunogen Region: |
1-349 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-349 of human GLB1 (NP_000395.3). |
| Immunogen Sequence: |
TSYDYDAPLSEAGDLTEKYF ALRNIIQKFEKVPEGPIPPS TPKFAYGKVTLEKLKTVGAA LDILCPSGPIKSLYPLTFIQ VKQHYGFVLYRTTLPQDCSN PAPLSSPLNGVHDRAYVAVD GIPQGVLERNNVITLNITGK AGATLDLLVENMGRVNYGAY INDFKGLVSNLTLSSNILTD WTIFPLDTEDAVCSHLGGWG HRDSGHHDEAWAHNSSNYTL PAFYMGNFSIPSGIPDLPQ |
| Tissue Specificity | Detected in placenta (at protein level). Detected in fibroblasts and testis. |
| Function | Isoform 1: Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Isoform 2: Has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers. |
| Protein Name | Beta-GalactosidaseAcid Beta-GalactosidaseLactaseElastin Receptor 1 |
| Database Links | Reactome: R-HSA-1660662Reactome: R-HSA-2022857Reactome: R-HSA-2024096Reactome: R-HSA-2206308Reactome: R-HSA-4085001Reactome: R-HSA-4341670Reactome: R-HSA-6798695 |
| Cellular Localisation | Isoform 1: LysosomeIsoform 2: CytoplasmPerinuclear RegionLocalized To The Perinuclear Area Of The Cytoplasm But Not To Lysosomes |
| Alternative Antibody Names | Anti-Beta-Galactosidase antibodyAnti-Acid Beta-Galactosidase antibodyAnti-Lactase antibodyAnti-Elastin Receptor 1 antibodyAnti-GLB1 antibodyAnti-ELNR1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
