| Short Description : | Rabbit polyclonal GK2 (1-150) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GK2 |
| Gene ID: | 2712 |
| Uniprot ID: | GLPK2_HUMAN |
| Immunogen Region: | 1-150 |
| Immunogen Sequence: | MAAPKTAAVGPLVGAVVQGT NSTRFLVFNSKTAELLSHHK VELTQEFPKEGWVEQDPKEI LQSVYECIARTCEKLDELNI DISNIKAVGVSNQRETTVIW DKLTGEPLYNAVVWLDLRTQ TTVEDLSKKIPGNSNFVKSK TGLPLSTYFS |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human GK2 (NP_149991.2). |
| Tissue Specificity | Testis-specific. Expressed in the midpiece of spermatozoa. |
| Function | Key enzyme in the regulation of glycerol uptake and metabolism. Essential for male fertility and sperm mitochondrial sheath formation. Required for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during spermatogenesis. Can induce mitochondrial clustering through interactions with PLD6 and up-regulation of phosphatidic acid synthesis in the mitochondria. |
| Protein Name | Glycerol Kinase 2Gk 2Glycerokinase 2Atp -Glycerol 3-Phosphotransferase 2Glycerol Kinase - Testis Specific 2 |
| Database Links | Reactome: R-HSA-75109 |
| Cellular Localisation | Mitochondrion Outer MembraneSingle-Pass Type Iv Membrane ProteinCytoplasmIn Sperm The Majority Of The Enzyme Is Bound To Mitochondria |
| Alternative Antibody Names | Anti-Glycerol Kinase 2 antibodyAnti-Gk 2 antibodyAnti-Glycerokinase 2 antibodyAnti-Atp -Glycerol 3-Phosphotransferase 2 antibodyAnti-Glycerol Kinase - Testis Specific 2 antibodyAnti-GK2 antibodyAnti-GKP2 antibodyAnti-GKTA antibody |
Information sourced from Uniprot.org
