| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GJA8 |
| Gene ID: | 2703 |
| Uniprot ID: | CXA8_HUMAN |
| Immunogen Region: | 234-433 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 234-433 of human GJA8 (NP_005258.2). |
| Immunogen Sequence: | SALKRPVEQPLGEIPEKSLH SIAVSSIQKAKGYQLLEEEK IVSHYFPLTEVGMVETSPLP AKPFNQFEEKISTGPLGDLS RGYQETLPSYAQVGAQEVEG EGPPAEEGAEPEVGEKKEEA ERLTTEEQEKVAVPEGEKVE TPGVDKEGEKEEPQSEKVSK QGLPAEKTPSLCPELTTDDA RPLSRLSKASSRARSDDLTV |
| Tissue Specificity | Eye lens. |
| Function | Structural component of eye lens gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore. |
| Protein Name | Gap Junction Alpha-8 ProteinConnexin-50Cx50Lens Fiber Protein Mp70 |
| Database Links | Reactome: R-HSA-190861 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell JunctionGap Junction |
| Alternative Antibody Names | Anti-Gap Junction Alpha-8 Protein antibodyAnti-Connexin-50 antibodyAnti-Cx50 antibodyAnti-Lens Fiber Protein Mp70 antibodyAnti-GJA8 antibody |
Information sourced from Uniprot.org