| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GINS4 |
| Gene ID: | 84296 |
| Uniprot ID: | SLD5_HUMAN |
| Immunogen Region: | 108-207 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 108-207 of human GINS4 (NP_115712.1). |
| Immunogen Sequence: | LEKEKTRPEGEPSSLSPEEL AFAREFMANTESYLKNVALK HMPPNLQKVDLFRAVPKPDL DSYVFLRVRERQENILVEPD TDEQRDYVIDLEKGSQHLIR |
| Function | Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. |
| Protein Name | Dna Replication Complex Gins Protein Sld5Gins Complex Subunit 4 Cleaved Into - Dna Replication Complex Gins Protein Sld5 - N-Terminally Processed |
| Database Links | Reactome: R-HSA-176974 |
| Cellular Localisation | NucleusChromosomeCytoplasmAssociates With Chromatin |
| Alternative Antibody Names | Anti-Dna Replication Complex Gins Protein Sld5 antibodyAnti-Gins Complex Subunit 4 Cleaved Into - Dna Replication Complex Gins Protein Sld5 - N-Terminally Processed antibodyAnti-GINS4 antibodyAnti-SLD5 antibody |
Information sourced from Uniprot.org