| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GIMAP5 |
| Gene ID: | 55340 |
| Uniprot ID: | GIMA5_HUMAN |
| Immunogen Region: | 190-270 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 190-270 of human GIMAP5 (NP_060854.2). |
| Immunogen Sequence: | WGSVEEQRQQQAELLAVIER LGREREGSFHSNDLFLDAQL LQRTGAGACQEDYRQYQAKV EWQVEKHKQELRENESNWAY K |
| Tissue Specificity | Widely expressed with high levels in lymph node and spleen. High expression found in T lymphocytes, including CD4 and CD8-positive T-cells, and monocytes. Very low expression levels in B-lymphocytes. |
| Function | Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes. Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation. Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function. May promote the survival of mature T lymphocytes upon cytokine withdrawal. May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation. May play a role in mitochondrial DNA segregation in hematopoietic tissues. Is a regulator of liver endothelial cell homeostasis. |
| Protein Name | Gtpase Imap Family Member 5 Immune-Associated Nucleotide-Binding Protein 5 Immunity-Associated Nucleotide 4-Like 1 Protein Immunity-Associated Nucleotide 5 Protein Ian-5 Hian5 Immunity-Associated Protein 3 |
| Cellular Localisation | Lysosome Membrane Single-Pass Type Iv Membrane Protein Endosome Multivesicular Body Membrane Endosome Membrane The Mitochondrial Localization Originally Reported Was Observed With C-Terminally Tagged Protein And Was Not Confirmed In Later Publications |
| Alternative Antibody Names | Anti-Gtpase Imap Family Member 5 antibody Anti-Immune-Associated Nucleotide-Binding Protein 5 antibody Anti-Immunity-Associated Nucleotide 4-Like 1 Protein antibody Anti-Immunity-Associated Nucleotide 5 Protein antibody Anti-Ian-5 antibody Anti-Hian5 antibody Anti-Immunity-Associated Protein 3 antibody Anti-GIMAP5 antibody Anti-IAN4L1 antibody Anti-IAN5 antibody Anti-IMAP3 antibody |
Information sourced from Uniprot.org