Anti-GIMAP5 antibody (190-270) (STJ116322)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GIMAP5 (190-270) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GIMAP5 |
| Gene ID | 55340 |
| Uniprot ID | GIMA5_HUMAN |
| Immunogen Region | 190-270 |
| Immunogen Sequence | WGSVEEQRQQQAELLAVIER LGREREGSFHSNDLFLDAQL LQRTGAGACQEDYRQYQAKV EWQVEKHKQELRENESNWAY K |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 190-270 of human GIMAP5 (NP_060854.2). |
Additional Info
| Tissue Specificity | Widely expressed with high levels in lymph node and spleen. High expression found in T lymphocytes, including CD4 and CD8-positive T-cells, and monocytes. Very low expression levels in B-lymphocytes. |
| Function | Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes. Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation. Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function. May promote the survival of mature T lymphocytes upon cytokine withdrawal. May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation. May play a role in mitochondrial DNA segregation in hematopoietic tissues. Is a regulator of liver endothelial cell homeostasis. |
| Protein Name | Gtpase Imap Family Member 5Immune-Associated Nucleotide-Binding Protein 5Immunity-Associated Nucleotide 4-Like 1 ProteinImmunity-Associated Nucleotide 5 ProteinIan-5Hian5Immunity-Associated Protein 3 |
| Database Links | |
| Cellular Localisation | Lysosome MembraneSingle-Pass Type Iv Membrane ProteinEndosomeMultivesicular Body MembraneEndosome MembraneThe Mitochondrial Localization Originally Reported Was Observed With C-Terminally Tagged Protein And Was Not Confirmed In Later Publications |
| Alternative Antibody Names | Anti-Gtpase Imap Family Member 5 antibodyAnti-Immune-Associated Nucleotide-Binding Protein 5 antibodyAnti-Immunity-Associated Nucleotide 4-Like 1 Protein antibodyAnti-Immunity-Associated Nucleotide 5 Protein antibodyAnti-Ian-5 antibodyAnti-Hian5 antibodyAnti-Immunity-Associated Protein 3 antibodyAnti-GIMAP5 antibodyAnti-IAN4L1 antibodyAnti-IAN5 antibodyAnti-IMAP3 antibody |
Information sourced from Uniprot.org