| Post Translational Modifications | Polyubiquitinated through 'Lys-48'-polyubiquitin chains, leading to proteasomal degradation in the absence of Wnt stimulation. |
| Function | Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation. |
| Protein Name | Glucose-Induced Degradation Protein 8 HomologTwo Hybrid-Associated Protein 1 With RanbpmTwa1 |
| Database Links | Reactome: R-HSA-9861718 |
| Cellular Localisation | CytoplasmNucleusLocalizes In The Cytoplasm In The Absence Of Wnt Stimulation And In The Nucleus In The Presence Of Wnt Stimulation |
| Alternative Antibody Names | Anti-Glucose-Induced Degradation Protein 8 Homolog antibodyAnti-Two Hybrid-Associated Protein 1 With Ranbpm antibodyAnti-Twa1 antibodyAnti-GID8 antibodyAnti-C20orf11 antibodyAnti-TWA1 antibody |
Information sourced from Uniprot.org
