| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Glucose-induced degradation protein 8 homolog (115-165 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GID8 |
| Gene ID: |
54994 |
| Uniprot ID: |
GID8_HUMAN |
| Immunogen Region: |
115-165 aa |
| Specificity: |
This antibody detects endogenous levels of human GID8 |
| Immunogen: |
Synthesized peptide derived from the human GID8 at the amino acid range 115-165 |
| Post Translational Modifications | Polyubiquitinated through 'Lys-48'-polyubiquitin chains, leading to proteasomal degradation in the absence of Wnt stimulation. |
| Function | Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation. |
| Protein Name | Glucose-Induced Degradation Protein 8 HomologTwo Hybrid-Associated Protein 1 With RanbpmTwa1 |
| Database Links | Reactome: R-HSA-9861718 |
| Cellular Localisation | CytoplasmNucleusLocalizes In The Cytoplasm In The Absence Of Wnt Stimulation And In The Nucleus In The Presence Of Wnt Stimulation |
| Alternative Antibody Names | Anti-Glucose-Induced Degradation Protein 8 Homolog antibodyAnti-Two Hybrid-Associated Protein 1 With Ranbpm antibodyAnti-Twa1 antibodyAnti-GID8 antibodyAnti-C20orf11 antibodyAnti-TWA1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
