| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Glucose-induced degradation protein 8 homolog (115-165 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GID8 |
| Gene ID: | 54994 |
| Uniprot ID: | GID8_HUMAN |
| Immunogen Region: | 115-165 aa |
| Specificity: | This antibody detects endogenous levels of human GID8 |
| Immunogen: | Synthesized peptide derived from the human GID8 at the amino acid range 115-165 |
| Post Translational Modifications | Polyubiquitinated through 'Lys-48'-polyubiquitin chains, leading to proteasomal degradation in the absence of Wnt stimulation. |
| Function | Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation. |
| Protein Name | Glucose-Induced Degradation Protein 8 Homolog Two Hybrid-Associated Protein 1 With Ranbpm Twa1 |
| Database Links | Reactome: R-HSA-9861718 |
| Cellular Localisation | Cytoplasm Nucleus Localizes In The Cytoplasm In The Absence Of Wnt Stimulation And In The Nucleus In The Presence Of Wnt Stimulation |
| Alternative Antibody Names | Anti-Glucose-Induced Degradation Protein 8 Homolog antibody Anti-Two Hybrid-Associated Protein 1 With Ranbpm antibody Anti-Twa1 antibody Anti-GID8 antibody Anti-C20orf11 antibody Anti-TWA1 antibody |
Information sourced from Uniprot.org