| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GGCX |
| Gene ID: | 2677 |
| Uniprot ID: | VKGC_HUMAN |
| Immunogen Region: | 479-758 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 479-758 of human GGCX (NP_000812.2). |
| Immunogen Sequence: | QRIFDPRVDIVQAAWSPFQR TSWVQPLLMDLSPWRAKLQE IKSSLDNHTEVVFIADFPGL HLENFVSEDLGNTSIQLLQG EVTVELVAEQKNQTLREGEK MQLPAGEYHKVYTTSPSPSC YMYVYVNTTELALEQDLAYL QELKEKVENGSETGPLPPEL QPLLEGEVKGGPEPTPLVQT FLRRQQRLQEIERRRNTPFH ERFFRFLLRKLYVFRRSFLM TCISLRNLILGRPSLEQLA |
| Function | Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. Catalyzes gamma-carboxylation of various proteins, such as blood coagulation factors (F2, F7, F9 and F10), osteocalcin (BGLAP) or matrix Gla protein (MGP). |
| Protein Name | Vitamin K-Dependent Gamma-Carboxylase Gamma-Glutamyl Carboxylase Peptidyl-Glutamate 4-Carboxylase Vitamin K Gamma Glutamyl Carboxylase |
| Database Links | Reactome: R-HSA-159740 Reactome: R-HSA-9673240 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Vitamin K-Dependent Gamma-Carboxylase antibody Anti-Gamma-Glutamyl Carboxylase antibody Anti-Peptidyl-Glutamate 4-Carboxylase antibody Anti-Vitamin K Gamma Glutamyl Carboxylase antibody Anti-GGCX antibody Anti-GC antibody |
Information sourced from Uniprot.org