| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-GGA2 (GAT domain) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | Gga2 |
| Gene ID: | 74105 |
| Uniprot ID: | GGA2_MOUSE |
| Immunogen Region: | GAT domain |
| Specificity: | Specific for GGA2. |
| Immunogen: | A synthetic peptide from the GAT domain of mouse GGA2 conjugated to an immunogenic carrier protein was used as the antigen. The antigen is homologous in rat. |
| Function | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network. |
| Protein Name | Adp-Ribosylation Factor-Binding Protein Gga2Gamma-Adaptin-Related Protein 2Golgi-Localized - Gamma Ear-Containing - Arf-Binding Protein 2 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi Network MembranePeripheral Membrane ProteinEndosome MembraneEarly Endosome Membrane |
| Alternative Antibody Names | Anti-Adp-Ribosylation Factor-Binding Protein Gga2 antibodyAnti-Gamma-Adaptin-Related Protein 2 antibodyAnti-Golgi-Localized - Gamma Ear-Containing - Arf-Binding Protein 2 antibodyAnti-Gga2 antibodyAnti-Kiaa1080 antibody |
Information sourced from Uniprot.org