| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Mouse/Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GGA1 (280-330 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
Gga1 |
| Gene ID: |
106039 |
| Uniprot ID: |
GGA1_MOUSE |
| Immunogen Region: |
280-330 aa |
| Specificity: |
Specific for GGA1. |
| Immunogen: |
A synthetic peptide from aa region 280-330 of mouse GGA1 conjugated to blue carrier protein was used as the antigen. The peptide shares 95% identity with human sequence. |
| Function | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane. Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network. |
| Protein Name | Adp-Ribosylation Factor-Binding Protein Gga1Gamma-Adaptin-Related Protein 1Golgi-Localized - Gamma Ear-Containing - Arf-Binding Protein 1 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi Network MembranePeripheral Membrane ProteinEndosome MembraneEarly Endosome Membrane |
| Alternative Antibody Names | Anti-Adp-Ribosylation Factor-Binding Protein Gga1 antibodyAnti-Gamma-Adaptin-Related Protein 1 antibodyAnti-Golgi-Localized - Gamma Ear-Containing - Arf-Binding Protein 1 antibodyAnti-Gga1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
