Western blot analysis of extracts of various cell lines, using GFRA2 antibody (STJ23776) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.

Anti-GFRA2 antibody (360-464) (STJ23776)

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STJ23776
£112.50 - £524.50
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:200-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GFRA2
Gene ID: 2675
Uniprot ID: GFRA2_HUMAN
Immunogen Region: 360-464
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 360-464 of human GFRA2 (NP_001486.4).
Immunogen Sequence: DVNVSPKGPSFQATQAPRVE KTPSLPDDLSDSTSLGTSVI TTCTSVQEQGLKANNSKELS MCFTELTTNIIPGSNKVIKP NSGPSRARPSAALTVLSVLM LKLAL
Tissue Specificity Isoform 1: found in both brain and placenta.
Function Receptor for neurturin (NRTN), a growth factor that supports the survival of sympathetic neurons. NRTN-binding leads to autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. Isoform 2: Participates in NRTN-induced 'Ser-727' phosphorylation of STAT3.
Protein Name Gdnf Family Receptor Alpha-2
Gdnf Receptor Alpha-2
Gdnfr-Alpha-2
Gfr-Alpha-2
Gdnf Receptor Beta
Gdnfr-Beta
Neurturin Receptor Alpha
Nrtnr-Alpha
Ntnr-Alpha
Ret Ligand 2
Tgf-Beta-Related Neurotrophic Factor Receptor 2
Database Links Reactome: R-HSA-419037
Reactome: R-HSA-5673001
Reactome: R-HSA-8853659
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Alternative Antibody Names Anti-Gdnf Family Receptor Alpha-2 antibody
Anti-Gdnf Receptor Alpha-2 antibody
Anti-Gdnfr-Alpha-2 antibody
Anti-Gfr-Alpha-2 antibody
Anti-Gdnf Receptor Beta antibody
Anti-Gdnfr-Beta antibody
Anti-Neurturin Receptor Alpha antibody
Anti-Nrtnr-Alpha antibody
Anti-Ntnr-Alpha antibody
Anti-Ret Ligand 2 antibody
Anti-Tgf-Beta-Related Neurotrophic Factor Receptor 2 antibody
Anti-GFRA2 antibody
Anti-GDNFRB antibody
Anti-RETL2 antibody
Anti-TRNR2 antibody

Information sourced from Uniprot.org

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