| Post Translational Modifications | Activation of SRC induces tyrosine phosphorylation of ARHGEF5. |
| Function | Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1. Involved in regulation of cell shape and actin cytoskeletal organization. Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia. Required for SRC-induced podosome formation. Involved in positive regulation of immature dendritic cell migration. |
| Protein Name | Rho Guanine Nucleotide Exchange Factor 5Ephexin-3Guanine Nucleotide Regulatory Protein TimOncogene TimTransforming Immortalized Mammary OncogeneP60 Tim |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013408 |
| Cellular Localisation | CytoplasmNucleusCell ProjectionPodosome |
| Alternative Antibody Names | Anti-Rho Guanine Nucleotide Exchange Factor 5 antibodyAnti-Ephexin-3 antibodyAnti-Guanine Nucleotide Regulatory Protein Tim antibodyAnti-Oncogene Tim antibodyAnti-Transforming Immortalized Mammary Oncogene antibodyAnti-P60 Tim antibodyAnti-ARHGEF5 antibodyAnti-TIM antibody |
Information sourced from Uniprot.org
