| Host: |
Goat |
| Applications: |
Pep-ELISA/WB/IHC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-GEF5 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-0.1-0.3µg/mlIHC-3.75µg/mlELISA-antibody detection limit dilution 1:16000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
ARHGEF5 |
| Gene ID: |
7984 |
| Uniprot ID: |
ARHG5_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_005426.2 |
| Immunogen Sequence: |
DKEIDQNSQQEE |
| Post Translational Modifications | Activation of SRC induces tyrosine phosphorylation of ARHGEF5. |
| Function | Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1. Involved in regulation of cell shape and actin cytoskeletal organization. Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia. Required for SRC-induced podosome formation. Involved in positive regulation of immature dendritic cell migration. |
| Protein Name | Rho Guanine Nucleotide Exchange Factor 5Ephexin-3Guanine Nucleotide Regulatory Protein TimOncogene TimTransforming Immortalized Mammary OncogeneP60 Tim |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013408 |
| Cellular Localisation | CytoplasmNucleusCell ProjectionPodosome |
| Alternative Antibody Names | Anti-Rho Guanine Nucleotide Exchange Factor 5 antibodyAnti-Ephexin-3 antibodyAnti-Guanine Nucleotide Regulatory Protein Tim antibodyAnti-Oncogene Tim antibodyAnti-Transforming Immortalized Mammary Oncogene antibodyAnti-P60 Tim antibodyAnti-ARHGEF5 antibodyAnti-TIM antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
