Immunofluorescence analysis of MCF7 cells using GDNF Receptor alpha 1/GFRA1 Rabbit mAb (STJ11107301) at a dilution of 1:100 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (STJS001166) at 1:500 dilution. Blue: DAPI for nuclear staining.

Anti-GDNF Receptor alpha 1/GFRA1 antibody (361-460 aa) [SRM] (STJ11107301)

SKU:
STJ11107301
€161.88 - €718.13
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Host: Rabbit
Applications: IF/ICC/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Monoclonal
Clone ID : SRM
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: IF/ICC:1:100-1:400
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Gene Symbol: GFRA1
Gene ID: 2674
Uniprot ID: GFRA1_HUMAN
Immunogen Region: 361-460 aa
Specificity: A synthetic peptide corresponding to a sequence within amino acids 361-460 of human GDNF Receptor alpha 1/GFRA1 (NP_005255.1).
Immunogen Sequence: QTTTATTTTALRVKNKPLGP AGSENEIPTHVLPPCANLQA QKLKSNVSGNTHLCISNGNY EKEGLGASSHITTKSMAAPP SCGLSPLLVLVVTALSTLLS
Function Coreceptor for GDNF, a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. GDNF-binding leads to autophosphorylation and activation of the RET receptor.
Protein Name Gdnf Family Receptor Alpha-1
Gdnf Receptor Alpha-1
Gdnfr-Alpha-1
Gfr-Alpha-1
Ret Ligand 1
Tgf-Beta-Related Neurotrophic Factor Receptor 1
Database Links Reactome: R-HSA-419037
Reactome: R-HSA-5673001
Reactome: R-HSA-8853659
Reactome: R-HSA-9830674
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Golgi Apparatus
Trans-Golgi Network
Endosome
Multivesicular Body
Localizes Mainly To The Plasma Membrane
In The Presence Of Sorl1
Shifts To Vesicular Structures
Including Trans-Golgi Network
Endosomes And Multivesicular Bodies
Alternative Antibody Names Anti-Gdnf Family Receptor Alpha-1 antibody
Anti-Gdnf Receptor Alpha-1 antibody
Anti-Gdnfr-Alpha-1 antibody
Anti-Gfr-Alpha-1 antibody
Anti-Ret Ligand 1 antibody
Anti-Tgf-Beta-Related Neurotrophic Factor Receptor 1 antibody
Anti-GFRA1 antibody
Anti-GDNFRA antibody
Anti-RETL1 antibody
Anti-TRNR1 antibody

Information sourced from Uniprot.org

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