Anti-GDNF antibody [3C1] (STJA0002911)

Anti-GDNF antibody [3C1] (STJA0002911)

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STJA0002911
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Covered by St John's Laboratory Guarantee

Host: Mouse
Applications: ELISA/WB/IF/IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-GDNF is suitable for use in ELISA, Western Blot, Immunofluorescence and Immunohistochemistry research applications.
Clonality : Monoclonal
Clone ID : 3C1
Conjugation: Unconjugated
Isotype: murine IgG1
Formulation: PBS pH 7.4, with 0.1% sodium azide
Purification: Protein G purification
Dilution Range: ELISA 50 to 100 ng/ml; Western immunoblotting 2 to 5 µg/ml ; IF 2 to 10 µg/ml; IHC 5 µg/ml. Monoclonal antibody working amount has to be established practically for each particular antigen and assay format
Storage Instruction: Store at-20 to-70°C upon receipt. Divide antibody into aliquots prior usage. Avoid multiple freeze-thaw cycles
Gene Symbol: GDNF
Gene ID: 2668
Uniprot ID: GDNF_HUMAN
Specificity: Human GDNF
Immunogen: Recombinant human GDNF protein produced using E. coli expression system. Human GDNF
Tissue Specificity In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen. Isoform 2 is absent from most tissues except for low levels in intestine and kidney. Highest expression of isoform 3 is found in pancreatic islets. Isoform 5 is expressed at very low levels in putamen, nucleus accumbens, prefrontal cortex, amygdala, hypothalamus and intestine. Isoform 3 is up-regulated in the middle temporal gyrus of Alzheimer disease patients while isoform 2 shows no change.
Function Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. Acts by binding to its coreceptor, GFRA1, leading to autophosphorylation and activation of the RET receptor. Involved in the development of the neural crest.
Protein Name Glial Cell Line-Derived Neurotrophic Factor
Hgdnf
Astrocyte-Derived Trophic Factor
Atf
Database Links Reactome: R-HSA-419037
Reactome: R-HSA-5673001
Reactome: R-HSA-8853659
Reactome: R-HSA-9830674
Cellular Localisation Secreted
Alternative Antibody Names Anti-Glial Cell Line-Derived Neurotrophic Factor antibody
Anti-Hgdnf antibody
Anti-Astrocyte-Derived Trophic Factor antibody
Anti-Atf antibody
Anti-GDNF antibody

Information sourced from Uniprot.org

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