| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Growth/Differentiation Factor 15 (197-308) is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GDF15 |
| Gene ID: |
9518 |
| Uniprot ID: |
GDF15_HUMAN |
| Immunogen Region: |
197-308 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 197-308 of human GDF15 (NP_004855.2). |
| Immunogen Sequence: |
ARNGDHCPLGPGRCCRLHTV RASLEDLGWADWVLSPREVQ VTMCIGACPSQFRAANMHAQ IKTSLHRLKPDTVPAPCCVP ASYNPMVLIQKTDTGVSLQT YDDLLAKDCHCI |
| Tissue Specificity | Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney. Detected in plasma (at protein level). |
| Function | Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions. On hepatocytes, inhibits growth hormone signaling. |
| Protein Name | Growth/Differentiation Factor 15Gdf-15Macrophage Inhibitory Cytokine 1Mic-1Nsaid-Activated Gene 1 ProteinNag-1Nsaid-Regulated Gene 1 ProteinNrg-1Placental Tgf-BetaPlacental Bone Morphogenetic ProteinProstate Differentiation Factor |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Growth/Differentiation Factor 15 antibodyAnti-Gdf-15 antibodyAnti-Macrophage Inhibitory Cytokine 1 antibodyAnti-Mic-1 antibodyAnti-Nsaid-Activated Gene 1 Protein antibodyAnti-Nag-1 antibodyAnti-Nsaid-Regulated Gene 1 Protein antibodyAnti-Nrg-1 antibodyAnti-Placental Tgf-Beta antibodyAnti-Placental Bone Morphogenetic Protein antibodyAnti-Prostate Differentiation Factor antibodyAnti-GDF15 antibodyAnti-MIC1 antibodyAnti-PDF antibodyAnti-PLAB antibodyAnti-PTGFB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
