| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Growth/differentiation factor 11 (217-267 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GDF11 |
| Gene ID: |
10220 |
| Uniprot ID: |
GDF11_HUMAN |
| Immunogen Region: |
217-267 aa |
| Specificity: |
This antibody detects endogenous levels of GDF11 at Human/Mouse/Rat |
| Immunogen: |
Synthesized peptide derived from the human GDF11 at the amino acid range 217-267 |
| Post Translational Modifications | Synthesized as large precursor molecule that undergoes proteolytic cleavage by furin-like proteases. This produces an inactive form consisting of the mature C-terminal portion non-covalently bound to its cleaved N-terminal propeptide. Activation of the mature form requires additional cleavage of the propeptide by a tolloid-like metalloproteinase. |
| Function | Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues. It is required for proper vertebral patterning and orofacial development. Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3. |
| Protein Name | Growth/Differentiation Factor 11Gdf-11Bone Morphogenetic Protein 11Bmp-11 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Growth/Differentiation Factor 11 antibodyAnti-Gdf-11 antibodyAnti-Bone Morphogenetic Protein 11 antibodyAnti-Bmp-11 antibodyAnti-GDF11 antibodyAnti-BMP11 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
