Anti-GDF11 antibody (217-267 aa) (STJ195354)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human GDF11 at the amino acid range 217-267
General Information
| Short Description | Rabbit polyclonal anti-Growth/differentiation factor 11 (217-267 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GDF11 |
| Gene ID | 10220 |
| Uniprot ID | GDF11_HUMAN |
| Immunogen | Synthesized peptide derived from the human GDF11 at the amino acid range 217-267 |
| Immunogen Region | 217-267 aa |
| Specificity | This antibody detects endogenous levels of GDF11 at Human/Mouse/Rat |
Additional Info
| Post Translational Modifications | Synthesized as large precursor molecule that undergoes proteolytic cleavage by furin-like proteases. This produces an inactive form consisting of the mature C-terminal portion non-covalently bound to its cleaved N-terminal propeptide. Activation of the mature form requires additional cleavage of the propeptide by a tolloid-like metalloproteinase. |
| Function | Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues. It is required for proper vertebral patterning and orofacial development. Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3. |
| Protein Name | Growth/Differentiation Factor 11Gdf-11Bone Morphogenetic Protein 11Bmp-11 |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Growth/Differentiation Factor 11 antibodyAnti-Gdf-11 antibodyAnti-Bone Morphogenetic Protein 11 antibodyAnti-Bmp-11 antibodyAnti-GDF11 antibodyAnti-BMP11 antibody |
Information sourced from Uniprot.org