| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GCM1 |
| Gene ID: | 8521 |
| Uniprot ID: | GCM1_HUMAN |
| Immunogen Region: | 207-436 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 207-436 of human GCM1 (NP_003634.2). |
| Immunogen Sequence: | SFQEGVQLPGSYSGHLIANT PQQNSLNDCFSFSKSYGLGG ITDLTDQTSTVDPMKLYEKR KLSSSRTYSSGDLLPPSASG VYSDHGDLQAWSKNAALGRN HLADNCYSNYPFPLTSWPCS FSPSQNSSEPFYQQLPLEPP AAKTGCPPLWPNPAGNLYEE KVHVDFNSYVQSPAYHSPQE DPFLFTYASHPHQQYSLPSK SSKWDFEEEMTYLGLDHCNN DMLLNLCPLR |
| Tissue Specificity | Highly expressed in the placenta. Expressed in trophoblast cells of the villi. |
| Post Translational Modifications | Polyubiquitinated in the presence of UBE2D2 and FBXW2 (in vitro). |
| Function | Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer. Binds to the SYDE1 promoter. Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development. |
| Protein Name | Chorion-Specific Transcription Factor GcmaHgcmaGcm Motif Protein 1Glial Cells Missing Homolog 1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Chorion-Specific Transcription Factor Gcma antibodyAnti-Hgcma antibodyAnti-Gcm Motif Protein 1 antibodyAnti-Glial Cells Missing Homolog 1 antibodyAnti-GCM1 antibodyAnti-GCMA antibody |
Information sourced from Uniprot.org