| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:3000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GCLC |
| Gene ID: |
2729 |
| Uniprot ID: |
GSH1_HUMAN |
| Immunogen Region: |
1-252 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-252 of human GCLC (NP_001489.1). |
| Immunogen Sequence: |
MGLLSQGSPLSWEETKRHAD HVRRHGILQFLHIYHAVKDR HKDVLKWGDEVEYMLVSFDH ENKKVRLVLSGEKVLETLQE KGERTNPNHPTLWRPEYGSY MIEGTPGQPYGGTMSEFNTV EANMRKRRKEATSILEENQA LCTITSFPRLGCPGFTLPEV KPNPVEGGASKSLFFPDEAI NKHPRFSTLTRNIRHRRGEK VVINVPIFKDKNTPSPFIET FTEDDEASRASKPDHIYMD |
| Function | Catalyzes the ATP-dependent ligation of L-glutamate and L-cysteine and participates in the first and rate-limiting step in glutathione biosynthesis. |
| Protein Name | Glutamate--Cysteine Ligase Catalytic SubunitGcs Heavy ChainGamma-EcsGamma-Glutamylcysteine Synthetase |
| Database Links | Reactome: R-HSA-174403Reactome: R-HSA-5578999Reactome: R-HSA-9818027 |
| Alternative Antibody Names | Anti-Glutamate--Cysteine Ligase Catalytic Subunit antibodyAnti-Gcs Heavy Chain antibodyAnti-Gamma-Ecs antibodyAnti-Gamma-Glutamylcysteine Synthetase antibodyAnti-GCLC antibodyAnti-GLCL antibodyAnti-GLCLC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
