| Host: |
Goat |
| Applications: |
Pep-ELISA/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-GCH1 (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
IHC-5µg/mlELISA-antibody detection limit dilution 1:16000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
GCH1 |
| Gene ID: |
2643 |
| Uniprot ID: |
GCH1_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_000152.1 ; NP_001019195.1 ; NP_001019241.1 ; NP_001019242.1 |
| Specificity: |
This antibody is expected to recognize all four isoforms (NP_000152.1 ; NP_001019195.1 ; NP_001019241.1 ; NP_001019242.1) |
| Immunogen Sequence: |
GKVHIGYLPNKQ |
| Post Translational Modifications | Phosphorylated by casein kinase II at Ser-81 in HAECs during oscillatory shear stress.phosphorylation at Ser-81 results in increased enzyme activity. |
| Function | Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown. |
| Protein Name | Gtp Cyclohydrolase 1Gtp Cyclohydrolase IGtp-Ch-I |
| Database Links | Reactome: R-HSA-1474151 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Gtp Cyclohydrolase 1 antibodyAnti-Gtp Cyclohydrolase I antibodyAnti-Gtp-Ch-I antibodyAnti-GCH1 antibodyAnti-DYT5 antibodyAnti-GCH antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
