| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GC |
| Gene ID: | 2638 |
| Uniprot ID: | VTDB_HUMAN |
| Immunogen Region: | 324-493 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 324-493 of human Vitamin D Binding protein (NP_001191236.1). |
| Immunogen Sequence: | AMDVFVCTYFMPAAQLPELP DVELPTNKDVCDPGNTKVMD KYTFELSRRTHLPEVFLSKV LEPTLKSLGECCDVEDSTTC FNAKGPLLKKELSSFIDKGQ ELCADYSENTFTEYKKKLAE RLKAKLPDATPTELAKLVNK HSDFASNCCSINSPPLYCDS EIDAELKNIL |
| Tissue Specificity | Expressed in the liver. Found in plasma, ascites, cerebrospinal fluid and urine. |
| Post Translational Modifications | Allele GC*1S is O-glycosylated at Thr-436. The trisaccharide sugar moiety can be modified by the successive removal of neuraminic acid and galactose leaving an O-mceeN-acetyl-galactosamine. This conversion is thought to produce a macrophage-activating factor (Gc-MAF). Only a minor proportion of plasma GC is O-glycosylated. The potential N-glycosylation site predicted at Asn-288 is thought to be nonglycosylated. |
| Function | Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation. |
| Protein Name | Vitamin D-Binding Protein Dbp Vdb Gc Protein-Derived Macrophage Activating Factor Gc-Maf Gcmaf Gc-Globulin Group-Specific Component Gc Vitamin D-Binding Protein-Macrophage Activating Factor Dbp-Maf |
| Database Links | Reactome: R-HSA-196791 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Vitamin D-Binding Protein antibody Anti-Dbp antibody Anti-Vdb antibody Anti-Gc Protein-Derived Macrophage Activating Factor antibody Anti-Gc-Maf antibody Anti-Gcmaf antibody Anti-Gc-Globulin antibody Anti-Group-Specific Component antibody Anti-Gc antibody Anti-Vitamin D-Binding Protein-Macrophage Activating Factor antibody Anti-Dbp-Maf antibody Anti-GC antibody |
Information sourced from Uniprot.org