| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GBA2 |
| Gene ID: | 57704 |
| Uniprot ID: | GBA2_HUMAN |
| Immunogen Region: | 708-927 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 708-927 of human GBA2 (NP_065995.1). |
| Immunogen Sequence: | AQDIQDKFSSILSRGQEAYE RLLWNGRYYNYDSSSRPQSR SVMSDQCAGQWFLKACGLGE GDTEVFPTQHVVRALQTIFE LNVQAFAGGAMGAVNGMQPH GVPDKSSVQSDEVWVGVVYG LAATMIQEGLTWEGFQTAEG CYRTVWERLGLAFQTPEAYC QQRVFRSLAYMRPLSIWAMQ LALQQQQHKKASWPKVKQGT GLRTGPMFGPKEAMANLSPE |
| Tissue Specificity | Widely expressed. Mainly expressed in brain, heart, skeletal muscle, kidney and placenta and expressed at lower levels in liver, spleen, small intestine and lung. Detectable in colon, thymus and peripheral blood leukocytes. |
| Function | Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramides/GlcCers (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) to free glucose and ceramides (such as N-acylsphing-4-enine). GlcCers are membrane glycosphingolipids that have a wide intracellular distribution. They are the main precursors of more complex glycosphingolipids that play a role in cellular growth, differentiation, adhesion, signaling, cytoskeletal dynamics and membrane properties. Involved in the transglucosylation of cholesterol, transfers glucose from GlcCer to cholesterol, thereby modifying its water solubility and biological properties. Under specific conditions, may catalyze the reverse reaction, transferring glucose from cholesteryl-3-beta-D-glucoside to ceramide (such as N-acylsphing-4-enine) (Probable). May play a role in the metabolism of bile acids. Able to hydrolyze bile acid 3-O-glucosides as well as to produce bile acid-glucose conjugates thanks to a bile acid glucosyl transferase activity. Catalyzes the hydrolysis of galactosylceramides/GalCers (such as beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine), as well as the galactosyl transfer between GalCers and cholesterol in vitro with lower activity compared with their activity against GlcCers. |
| Protein Name | Non-Lysosomal Glucosylceramidase Nlgase Beta-Glucocerebrosidase 2 Beta-Glucosidase 2 Bile Acid Beta-Glucosidase Gba2 Bile Acid Glucosyl Transferase Gba2 Cholesterol Glucosyltransferase Gba2 Cholesteryl-Beta-Glucosidase Gba2 Glucosylceramidase 2 Non-Lysosomal Cholesterol Glycosyltransferase Non-Lysosomal Galactosylceramidase Non-Lysosomal Glycosylceramidase |
| Database Links | Reactome: R-HSA-9840310 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Peripheral Membrane Protein Cytoplasmic Side Golgi Apparatus Membrane Localization To The Plasma Membrane And Alternative Topologies Have Also Been Reported |
| Alternative Antibody Names | Anti-Non-Lysosomal Glucosylceramidase antibody Anti-Nlgase antibody Anti-Beta-Glucocerebrosidase 2 antibody Anti-Beta-Glucosidase 2 antibody Anti-Bile Acid Beta-Glucosidase Gba2 antibody Anti-Bile Acid Glucosyl Transferase Gba2 antibody Anti-Cholesterol Glucosyltransferase Gba2 antibody Anti-Cholesteryl-Beta-Glucosidase Gba2 antibody Anti-Glucosylceramidase 2 antibody Anti-Non-Lysosomal Cholesterol Glycosyltransferase antibody Anti-Non-Lysosomal Galactosylceramidase antibody Anti-Non-Lysosomal Glycosylceramidase antibody Anti-GBA2 antibody Anti-KIAA1605 antibody Anti-SPG46 antibody Anti-AD035 antibody |
Information sourced from Uniprot.org