| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GAD2 |
| Gene ID: | 2572 |
| Uniprot ID: | DCE2_HUMAN |
| Immunogen Region: | 401-585 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 401-585 of human GAD65/GAD2 (NP_001127838.1). |
| Immunogen Sequence: | PLQCSALLVREEGLMQNCNQ MHASYLFQQDKHYDLSYDTG DKALQCGRHVDVFKLWLMWR AKGTTGFEAHVDKCLELAEY LYNIIKNREGYEMVFDGKPQ HTNVCFWYIPPSLRTLEDNE ERMSRLSKVAPVIKARMMEY GTTMVSYQPLGDKVNFFRMV ISNPAATHQDIDFLIEEIER LGQDL |
| Post Translational Modifications | Phosphorylated.which does not affect kinetic parameters or subcellular location. Palmitoylated.which is required for presynaptic clustering. |
| Function | Catalyzes the production of GABA. |
| Protein Name | Glutamate Decarboxylase 265 Kda Glutamic Acid DecarboxylaseGad-65Glutamate Decarboxylase 65 Kda Isoform |
| Database Links | Reactome: R-HSA-888568Reactome: R-HSA-888590Reactome: R-HSA-9022927 |
| Cellular Localisation | CytoplasmCytosolCytoplasmic VesiclePresynaptic Cell MembraneLipid-AnchorGolgi Apparatus MembranePeripheral Membrane ProteinCytoplasmic SideAssociated To Cytoplasmic VesiclesIn NeuronsCytosolic Leaflet Of Golgi Membranes And Presynaptic Clusters |
| Alternative Antibody Names | Anti-Glutamate Decarboxylase 2 antibodyAnti-65 Kda Glutamic Acid Decarboxylase antibodyAnti-Gad-65 antibodyAnti-Glutamate Decarboxylase 65 Kda Isoform antibodyAnti-GAD2 antibodyAnti-GAD65 antibody |
Information sourced from Uniprot.org