• Western blot of mouse brain lysates from wild type (WT) and Alpha 2-knockout (K/O) animals showing specific immunolabeling of the ~51 kDa Alpha 2-subunit of the GABAA-R. The labeling was absent from a lysate prepared from Alpha 2-knockout animals.
  • Western blot of rat cortical neurons showing specific immunolabeling of the ~51 kDa Alpha 2-subunit of the GABAA-R (1:1000). Image kindly provided by Lidong Liu, University of British Columbia, Vancouver.

Anti-GABRA2 antibody (Cytoplasmic Loop) (STJA0003641)

SKU:
STJA0003641-100

£442.50
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Host: Rabbit
Applications: WB/ICC
Reactivity: Mouse/Bovine/Canine/Human/Non-Human Primates/Rat/Zebrafish
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-GABA A Receptor a 2 (Cytoplasmic Loop) is suitable for use in Western Blot and Immunocytochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol.
Purification: This antibody was antigen affinity purified from pooled serum.
Dilution Range: WB 1:1000
IHC
ICC 1:1000
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Gabra2Uniprot ID=GBRA2_RAT"
Immunogen Region: Cytoplasmic Loop
Immunogen: Fusion protein from the cytoplasmic loop of the alpha 2 subunit.
Tissue Specificity Expressed in brain (at protein level).
Post Translational Modifications Glycosylated.
Function Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The alpha2/beta2/gamma2 receptor exhibits synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity.
Protein Name Gamma-Aminobutyric Acid Receptor Subunit Alpha-2
Gaba(A Receptor Subunit Alpha-2
Cellular Localisation Postsynaptic Cell Membrane
Multi-Pass Membrane Protein
Cell Membrane
Cytoplasmic Vesicle Membrane
Cell Projection
Dendrite
Alternative Antibody Names Anti-Gamma-Aminobutyric Acid Receptor Subunit Alpha-2 antibody
Anti-Gaba(A Receptor Subunit Alpha-2 antibody
Anti-Gabra2 antibody
Anti-Gabra-2 antibody

Information sourced from Uniprot.org

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