| Host: |
Rabbit |
| Applications: |
IHC/IF |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Gamma-aminobutyric acid type B receptor subunit 2 (785-835 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC 1:100-200IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GABBR2 |
| Gene ID: |
9568 |
| Uniprot ID: |
GABR2_HUMAN |
| Immunogen Region: |
785-835 aa |
| Specificity: |
GABA B Receptor 2 protein (A228) detects endogenous levels of GABA B Receptor 2 |
| Immunogen: |
Synthetic peptide derived from GABA B Receptor 2 at the amino acid range 785-835 |
| Function | Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). |
| Protein Name | Gamma-Aminobutyric Acid Type B Receptor Subunit 2Gaba-B Receptor 2Gaba-B-R2Gaba-Br2Gababr2Gb2G-Protein Coupled Receptor 51Hg20 |
| Database Links | Reactome: R-HSA-1296041Reactome: R-HSA-418594Reactome: R-HSA-420499Reactome: R-HSA-977444Reactome: R-HSA-997272 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell MembraneCoexpression Of Gabbr1 And Gabbr2 Is Required For Gabbr1 Maturation And Transport To The Plasma MembraneIn ContrastGabbr2 Does Not Depend On Gabbr1 For Transport To The Cell Membrane |
| Alternative Antibody Names | Anti-Gamma-Aminobutyric Acid Type B Receptor Subunit 2 antibodyAnti-Gaba-B Receptor 2 antibodyAnti-Gaba-B-R2 antibodyAnti-Gaba-Br2 antibodyAnti-Gababr2 antibodyAnti-Gb2 antibodyAnti-G-Protein Coupled Receptor 51 antibodyAnti-Hg20 antibodyAnti-GABBR2 antibodyAnti-GPR51 antibodyAnti-GPRC3B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
