| Host: | Rabbit |
| Applications: | WB/ICC/IF/FC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal anti-GAB1 for use in WB, ICC, IF and FC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Monoclonal |
| Clone ID : | R04-3R6 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification: | Affinity Chromatography |
| Dilution Range: | WB 1:500-1:1000IF 1:50-1:200FC 1:50-1:100 |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | GAB1 |
| Gene ID: | 2549 |
| Uniprot ID: | GAB1_HUMAN |
| Immunogen: | A synthesized peptide derived from human GAB1 |
| Post Translational Modifications | Phosphorylated in response to FGFR1 activation. Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains. Phosphorylated on tyrosine residues by HCK upon IL6 signaling. |
| Function | Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway. |
| Protein Name | Grb2-Associated-Binding Protein 1Grb2-Associated Binder 1Growth Factor Receptor Bound Protein 2-Associated Protein 1 |
| Database Links | Reactome: R-HSA-109704Reactome: R-HSA-1236382Reactome: R-HSA-1257604Reactome: R-HSA-180292Reactome: R-HSA-1963642Reactome: R-HSA-2219530Reactome: R-HSA-5637810Reactome: R-HSA-5654689Reactome: R-HSA-5654695Reactome: R-HSA-5654710Reactome: R-HSA-5654720Reactome: R-HSA-5655253Reactome: R-HSA-5655291Reactome: R-HSA-5655302Reactome: R-HSA-5655332Reactome: R-HSA-6811558Reactome: R-HSA-8851907Reactome: R-HSA-8853659Reactome: R-HSA-8865999Reactome: R-HSA-8875555Reactome: R-HSA-8875656Reactome: R-HSA-9027276Reactome: R-HSA-9028335Reactome: R-HSA-9664565Reactome: R-HSA-9665348 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Grb2-Associated-Binding Protein 1 antibodyAnti-Grb2-Associated Binder 1 antibodyAnti-Growth Factor Receptor Bound Protein 2-Associated Protein 1 antibodyAnti-GAB1 antibody |
Information sourced from Uniprot.org
