Post Translational Modifications | (Microbial infection) Cleaved by foot-and-mouth disease virus leader protease.this cleavage suppresses the formation of cytoplasmic stress granules. |
Function | Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling. Plays an essential role in stress granule formation. Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress. Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations. |
Protein Name | Ras Gtpase-Activating Protein-Binding Protein 2G3bp-2Gap Sh3 Domain-Binding Protein 2 |
Database Links | Reactome: R-HSA-9705671 |
Cellular Localisation | CytoplasmStress Granule |
Alternative Antibody Names | Anti-Ras Gtpase-Activating Protein-Binding Protein 2 antibodyAnti-G3bp-2 antibodyAnti-Gap Sh3 Domain-Binding Protein 2 antibodyAnti-G3BP2 antibodyAnti-KIAA0660 antibody |
Information sourced from Uniprot.org