| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-G3BP2 (140-280) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
G3BP2 |
| Gene ID: |
9908 |
| Uniprot ID: |
G3BP2_HUMAN |
| Immunogen Region: |
140-280 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 140-280 of human G3BP2 (NP_987100.1). |
| Immunogen Sequence: |
DSEPELDEESEDEVEEEQEE RQPSPEPVQENANSGYYEAH PVTNGIEEPLEESSHEPEPE PESETKTEELKPQVEEKNLE ELEEKSTTPPPAEPVSLPQE PPKPRVEAKPEVQSQPPRVR EQRPRERPGFPPRGPRPGRG D |
| Post Translational Modifications | (Microbial infection) Cleaved by foot-and-mouth disease virus leader protease.this cleavage suppresses the formation of cytoplasmic stress granules. |
| Function | Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling. Plays an essential role in stress granule formation. Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress. Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations. |
| Protein Name | Ras Gtpase-Activating Protein-Binding Protein 2G3bp-2Gap Sh3 Domain-Binding Protein 2 |
| Database Links | Reactome: R-HSA-9705671 |
| Cellular Localisation | CytoplasmStress Granule |
| Alternative Antibody Names | Anti-Ras Gtpase-Activating Protein-Binding Protein 2 antibodyAnti-G3bp-2 antibodyAnti-Gap Sh3 Domain-Binding Protein 2 antibodyAnti-G3BP2 antibodyAnti-KIAA0660 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
