| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FYB1 |
| Gene ID: | 2533 |
| Uniprot ID: | FYB1_HUMAN |
| Immunogen Region: | 678-829 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 678-829 of human FYB (NP_001456.3). |
| Immunogen Sequence: | NEGSSFPAPPKQLDMGDEVY DDVDTSDFPVSSAEMSQGTN VGKAKTEEKDLKKLKKQEKE EKDFRKKFKYDGEIRVLYST KVTTSITSKKWGTRDLQVKP GESLEVIQTTDDTKVLCRNE EGKYGYVLRSYLADNDGEIY DDIADGCIYDND |
| Tissue Specificity | Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues. |
| Post Translational Modifications | T-cell receptor ligation leads to increased tyrosine phosphorylation. |
| Function | Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton. Modulates the expression of IL2. Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. |
| Protein Name | Fyn-Binding Protein 1 Adhesion And Degranulation Promoting Adaptor Protein Adap Fyb-120/130 P120/P130 Fyn-T-Binding Protein Slap-130 Slp-76-Associated Phosphoprotein |
| Database Links | Reactome: R-HSA-202433 Reactome: R-HSA-391160 |
| Cellular Localisation | Cytoplasm Nucleus Cell Junction Colocalizes With Tmem47 At Cell-Cell Contacts In Podocytes |
| Alternative Antibody Names | Anti-Fyn-Binding Protein 1 antibody Anti-Adhesion And Degranulation Promoting Adaptor Protein antibody Anti-Adap antibody Anti-Fyb-120/130 antibody Anti-P120/P130 antibody Anti-Fyn-T-Binding Protein antibody Anti-Slap-130 antibody Anti-Slp-76-Associated Phosphoprotein antibody Anti-FYB1 antibody Anti-FYB antibody Anti-SLAP130 antibody |
Information sourced from Uniprot.org