| Host: | Mouse |
| Applications: | ELISA/WB/ICC/IP |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal anti-FXYD5/Dysadherin (ECD) for use in ELISA, WB, ICC and IP in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Monoclonal |
| Clone ID : | M029 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Purification: | Protein G Purified |
| Dilution Range: | WB 1:1000ICC 1:100IP 1:100 |
| Storage Instruction: | Storage at-20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at-20°C. |
| Gene Symbol: | FXYD5 |
| Gene ID: | 53827 |
| Uniprot ID: | FXYD5_HUMAN |
| Immunogen Region: | ECD |
| Specificity: | Clone M029 mouse monoclonal antibody detects a 35-55 kDa* band on SDS-PAGE immunoblots of human A431, A549, MeWo, MDA-MB-231 cell, as well as human breast, lung, and skin tissues. The antibody works for western blot, immunoprecipitation, ELISA, and i |
| Immunogen: | Clone (M029) was generated from a proprietary antigen related to the native human FXYD5 protein expressed in A431 epidermoid carcinoma cell line. |
| Immunogen Sequence: | Human |
| Post Translational Modifications | Glycosylated. |
| Function | Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. May increase NKA activity by increasing the apparent affinity for Na(+). Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis. |
| Protein Name | Fxyd Domain-Containing Ion Transport Regulator 5Dysadherin |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinBasolateral Cell MembraneIn Kidneys Localizes To The Basolateral Membrane Of The Connecting Tubule |
| Alternative Antibody Names | Anti-Fxyd Domain-Containing Ion Transport Regulator 5 antibodyAnti-Dysadherin antibodyAnti-FXYD5 antibodyAnti-DYSAD antibodyAnti-IWU1 antibodyAnti-HSPC113 antibodyAnti-UNQ2561 antibodyAnti-PRO6241 antibody |
Information sourced from Uniprot.org
