| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-RNA-binding protein FXR2 (551-600 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FXR2 |
| Gene ID: | 9513 |
| Uniprot ID: | FXR2_HUMAN |
| Immunogen Region: | 551-600 aa |
| Specificity: | FXR2 Polyclonal Antibody detects endogenous levels of FXR2 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human FXR2 at the amino acid range 551-600 |
| Function | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis. Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability. Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus. |
| Protein Name | Rna-Binding Protein Fxr2Fxr2pFmr1 Autosomal Homolog 2 |
| Cellular Localisation | CytoplasmCytoplasmic Ribonucleoprotein GranulePostsynapseSpecifically Localizes To Cytoplasmic Ribonucleoprotein Membraneless CompartmentsLocalization To The Post-Synaptic Region Is Dependent On Fmr1 |
| Alternative Antibody Names | Anti-Rna-Binding Protein Fxr2 antibodyAnti-Fxr2p antibodyAnti-Fmr1 Autosomal Homolog 2 antibodyAnti-FXR2 antibodyAnti-FMR1L2 antibody |
Information sourced from Uniprot.org
