| Host: | Rabbit |
| Applications: | IHC/IF/IHC/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Alpha-1, 3-fucosyltransferase 4 (22-71 aa) is suitable for use in Immunohistochemistry, Immunofluorescence, Immunohistochemistry and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC 1:100-1:300 ELISA 1:40000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FUT4 |
| Gene ID: | 2526 |
| Uniprot ID: | FUT4_HUMAN |
| Immunogen Region: | 22-71 aa |
| Specificity: | CD15 Polyclonal Antibody detects endogenous levels of CD15 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human FucT-IV at the amino acid range 22-71 |
| Function | Isoform Short: Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1->4)GlcNAc) glycan attached to N- or O-linked glycoproteins. Robustly fucosylates nonsialylated distal LacNAc unit of the polylactosamine chain to form Lewis X antigen (CD15), a glycan determinant known to mediate important cellular functions in development and immunity. Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6-sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins. Together with FUT7 contributes to SELE, SELL and SELP selectin ligand biosynthesis and selectin-dependent lymphocyte homing, leukocyte migration and blood leukocyte homeostasis. In a cell type specific manner, may also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE. Isoform Long: Does not generate Lewis X antigens. |
| Protein Name | Alpha-(1 -3-Fucosyltransferase 4 4-Galactosyl-N-Acetylglucosaminide 3-Alpha-L-Fucosyltransferase Elam-1 Ligand Fucosyltransferase Fucosyltransferase 4 Fucosyltransferase Iv Fuc-Tiv Fuct-Iv Galactoside 3-L-Fucosyltransferase |
| Database Links | Reactome: R-HSA-9037629 |
| Cellular Localisation | Golgi Apparatus Golgi Stack Membrane Single-Pass Type Ii Membrane Protein Membrane-Bound Form In Trans Cisternae Of Golgi |
| Alternative Antibody Names | Anti-Alpha-(1 -3-Fucosyltransferase 4 antibody Anti-4-Galactosyl-N-Acetylglucosaminide 3-Alpha-L-Fucosyltransferase antibody Anti-Elam-1 Ligand Fucosyltransferase antibody Anti-Fucosyltransferase 4 antibody Anti-Fucosyltransferase Iv antibody Anti-Fuc-Tiv antibody Anti-Fuct-Iv antibody Anti-Galactoside 3-L-Fucosyltransferase antibody Anti-FUT4 antibody Anti-ELFT antibody Anti-FCT3A antibody |
Information sourced from Uniprot.org