| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FUT4 (186-331) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FUT4 |
| Gene ID: |
2526 |
| Uniprot ID: |
FUT4_HUMAN |
| Immunogen Region: |
186-331 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 186-331 of human FUT4 (NP_002024.1). |
| Immunogen Sequence: |
SRPVGVLLWWEPFGGRDSAP RPPPDCRLRFNISGCRLLTD RASYGEAQAVLFHHRDLVKG PPDWPPPWGIQAHTAEEVDL RVLDYEEAAAAAEALATSSP RPPGQRWVWMNFESPSHSPG LRSLASNLFNWTLSYRADSD VFVPYG |
| Tissue Specificity | Isoform Short: Expressed at low levels in bone marrow-derived mesenchymal stem cells. Expressed in cord blood immature promyelocytes and in peripheral blood myeloid and lymphoid cell populations. |
| Function | Isoform Short: Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1->4)GlcNAc) glycan attached to N- or O-linked glycoproteins. Robustly fucosylates nonsialylated distal LacNAc unit of the polylactosamine chain to form Lewis X antigen (CD15), a glycan determinant known to mediate important cellular functions in development and immunity. Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6-sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins. Together with FUT7 contributes to SELE, SELL and SELP selectin ligand biosynthesis and selectin-dependent lymphocyte homing, leukocyte migration and blood leukocyte homeostasis. In a cell type specific manner, may also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE. Isoform Long: Does not generate Lewis X antigens. |
| Protein Name | Alpha-(1 -3-Fucosyltransferase 44-Galactosyl-N-Acetylglucosaminide 3-Alpha-L-FucosyltransferaseElam-1 Ligand FucosyltransferaseFucosyltransferase 4Fucosyltransferase IvFuc-TivFuct-IvGalactoside 3-L-Fucosyltransferase |
| Database Links | Reactome: R-HSA-9037629 |
| Cellular Localisation | Golgi ApparatusGolgi Stack MembraneSingle-Pass Type Ii Membrane ProteinMembrane-Bound Form In Trans Cisternae Of Golgi |
| Alternative Antibody Names | Anti-Alpha-(1 -3-Fucosyltransferase 4 antibodyAnti-4-Galactosyl-N-Acetylglucosaminide 3-Alpha-L-Fucosyltransferase antibodyAnti-Elam-1 Ligand Fucosyltransferase antibodyAnti-Fucosyltransferase 4 antibodyAnti-Fucosyltransferase Iv antibodyAnti-Fuc-Tiv antibodyAnti-Fuct-Iv antibodyAnti-Galactoside 3-L-Fucosyltransferase antibodyAnti-FUT4 antibodyAnti-ELFT antibodyAnti-FCT3A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
