| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FUT4 |
| Gene ID: | 2526 |
| Uniprot ID: | FUT4_HUMAN |
| Immunogen Region: | 186-331 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 186-331 of human FUT4 (NP_002024.1). |
| Immunogen Sequence: | SRPVGVLLWWEPFGGRDSAP RPPPDCRLRFNISGCRLLTD RASYGEAQAVLFHHRDLVKG PPDWPPPWGIQAHTAEEVDL RVLDYEEAAAAAEALATSSP RPPGQRWVWMNFESPSHSPG LRSLASNLFNWTLSYRADSD VFVPYG |
| Tissue Specificity | Isoform Short: Expressed at low levels in bone marrow-derived mesenchymal stem cells. Expressed in cord blood immature promyelocytes and in peripheral blood myeloid and lymphoid cell populations. |
| Function | Isoform Short: Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1->4)GlcNAc) glycan attached to N- or O-linked glycoproteins. Robustly fucosylates nonsialylated distal LacNAc unit of the polylactosamine chain to form Lewis X antigen (CD15), a glycan determinant known to mediate important cellular functions in development and immunity. Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6-sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins. Together with FUT7 contributes to SELE, SELL and SELP selectin ligand biosynthesis and selectin-dependent lymphocyte homing, leukocyte migration and blood leukocyte homeostasis. In a cell type specific manner, may also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE. Isoform Long: Does not generate Lewis X antigens. |
| Protein Name | Alpha-(1 -3-Fucosyltransferase 4 4-Galactosyl-N-Acetylglucosaminide 3-Alpha-L-Fucosyltransferase Elam-1 Ligand Fucosyltransferase Fucosyltransferase 4 Fucosyltransferase Iv Fuc-Tiv Fuct-Iv Galactoside 3-L-Fucosyltransferase |
| Database Links | Reactome: R-HSA-9037629 |
| Cellular Localisation | Golgi Apparatus Golgi Stack Membrane Single-Pass Type Ii Membrane Protein Membrane-Bound Form In Trans Cisternae Of Golgi |
| Alternative Antibody Names | Anti-Alpha-(1 -3-Fucosyltransferase 4 antibody Anti-4-Galactosyl-N-Acetylglucosaminide 3-Alpha-L-Fucosyltransferase antibody Anti-Elam-1 Ligand Fucosyltransferase antibody Anti-Fucosyltransferase 4 antibody Anti-Fucosyltransferase Iv antibody Anti-Fuc-Tiv antibody Anti-Fuct-Iv antibody Anti-Galactoside 3-L-Fucosyltransferase antibody Anti-FUT4 antibody Anti-ELFT antibody Anti-FCT3A antibody |
Information sourced from Uniprot.org