| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FSTL1 |
| Gene ID: | 11167 |
| Uniprot ID: | FSTL1_HUMAN |
| Immunogen Region: | 1-308 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-308 of human FSTL1 (NP_009016.1). |
| Immunogen Sequence: | MWKRWLALALALVAVAWVRA EEELRSKSKICANVFCGAGR ECAVTEKGEPTCLCIEQCKP HKRPVCGSNGKTYLNHCELH RDACLTGSKIQVDYDGHCKE KKSVSPSASPVVCYQSNRDE LRRRIIQWLEAEIIPDGWFS KGSNYSEILDKYFKNFDNGD SRLDSSEFLKFVEQNETAIN ITTYPDQENNKLLRGLCVDA LIELSDENADWKLSFQEFLK CLNPSFNPPEKKCALEDET |
| Tissue Specificity | Overexpressed in synovial tissues from rheumatoid arthritis. |
| Function | Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation. Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter. Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes. Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors. |
| Protein Name | Follistatin-Related Protein 1Follistatin-Like Protein 1 |
| Database Links | Reactome: R-HSA-201451Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Follistatin-Related Protein 1 antibodyAnti-Follistatin-Like Protein 1 antibodyAnti-FSTL1 antibodyAnti-FRP antibody |
Information sourced from Uniprot.org