| Host: | Mouse |
| Applications: | IHC/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Glutamate carboxypeptidase 2 (100-200 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Monoclonal |
| Clone ID : | ABT-PSMA |
| Conjugation: | Unconjugated |
| Isotype: | IgG1k |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range: | IHC-P 1:100-500 WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FOLH1 |
| Gene ID: | 2346 |
| Uniprot ID: | FOLH1_HUMAN |
| Immunogen Region: | 100-200 aa |
| Specificity: | This antibody detects endogenous levels of human Prostate-Specific Membrane Antigen (PSMA). Heat-induced epitope retrieval (HIER) Citrate buffer of pH6.0 was highly recommended as antigen repair metho |
| Immunogen: | Synthesized peptide derived from the human Prostate-Specific Membrane Antigen (PSMA) at the amino acid range 100-200 |
| Post Translational Modifications | The first two amino acids at the N-terminus of isoform PSMA' appear to be cleaved by limited proteolysis. The N-terminus is blocked. |
| Function | Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression. Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC. |
| Protein Name | Glutamate Carboxypeptidase 2 Cell Growth-Inhibiting Gene 27 Protein Folate Hydrolase 1 Folylpoly-Gamma-Glutamate Carboxypeptidase Fgcp Glutamate Carboxypeptidase Ii Gcpii Membrane Glutamate Carboxypeptidase Mgcp N-Acetylated-Alpha-Linked Acidic Dipeptidase I Naaladase I Prostate-Specific Membrane Antigen Psm Psma Pteroylpoly-Gamma-Glutamate Carboxypeptidase |
| Database Links | Reactome: R-HSA-8963693 |
| Cellular Localisation | Cell Membrane Single-Pass Type Ii Membrane Protein Isoform Psma': Cytoplasm |
| Alternative Antibody Names | Anti-Glutamate Carboxypeptidase 2 antibody Anti-Cell Growth-Inhibiting Gene 27 Protein antibody Anti-Folate Hydrolase 1 antibody Anti-Folylpoly-Gamma-Glutamate Carboxypeptidase antibody Anti-Fgcp antibody Anti-Glutamate Carboxypeptidase Ii antibody Anti-Gcpii antibody Anti-Membrane Glutamate Carboxypeptidase antibody Anti-Mgcp antibody Anti-N-Acetylated-Alpha-Linked Acidic Dipeptidase I antibody Anti-Naaladase I antibody Anti-Prostate-Specific Membrane Antigen antibody Anti-Psm antibody Anti-Psma antibody Anti-Pteroylpoly-Gamma-Glutamate Carboxypeptidase antibody Anti-FOLH1 antibody Anti-FOLH antibody Anti-NAALAD1 antibody Anti-PSM antibody Anti-PSMA antibody Anti-GIG27 antibody |
Information sourced from Uniprot.org