| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Formin-binding protein 1 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FNBP1 |
| Gene ID: |
23048 |
| Uniprot ID: |
FNBP1_HUMAN |
| Specificity: |
This antibody detects endogenous levels of FBP17 at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human FBP17 |
| Function | May act as a link between RND2 signaling and regulation of the actin cytoskeleton. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. |
| Protein Name | Formin-Binding Protein 1Formin-Binding Protein 17Hfbp17 |
| Database Links | Reactome: R-HSA-8856828Reactome: R-HSA-9013148Reactome: R-HSA-9013406Reactome: R-HSA-9013409Reactome: R-HSA-9696270 |
| Cellular Localisation | CytoplasmCytoskeletonCell CortexLysosomeCytoplasmic VesicleCell MembranePeripheral Membrane ProteinCytoplasmic SideMembraneClathrin-Coated PitEnriched In Cortical Regions Coincident With F-ActinAlso Localizes To Endocytic Vesicles And Lysosomes |
| Alternative Antibody Names | Anti-Formin-Binding Protein 1 antibodyAnti-Formin-Binding Protein 17 antibodyAnti-Hfbp17 antibodyAnti-FNBP1 antibodyAnti-FBP17 antibodyAnti-KIAA0554 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
