| Post Translational Modifications | Ubiquitinated by FBXL22, leading to proteasomal degradation. |
| Function | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization. Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events. |
| Protein Name | Filamin-CFln-CFlncAbp-280-Like ProteinAbp-LActin-Binding-Like ProteinFilamin-2Gamma-Filamin |
| Database Links | Reactome: R-HSA-446353 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane ProteinCytoskeletonMyofibrilSarcomereZ LineA Small Amount Localizes At MembranesIn Striated Muscle CellsIt Predominantly Localizes In Myofibrillar Z LinesWhile A Minor Fraction Localizes With SubsarcolemmeTargeting To Developing And Mature Z Lines Is Mediated By The Intradomain Insert |
| Alternative Antibody Names | Anti-Filamin-C antibodyAnti-Fln-C antibodyAnti-Flnc antibodyAnti-Abp-280-Like Protein antibodyAnti-Abp-L antibodyAnti-Actin-Binding-Like Protein antibodyAnti-Filamin-2 antibodyAnti-Gamma-Filamin antibodyAnti-FLNC antibodyAnti-ABPL antibodyAnti-FLN2 antibody |
Information sourced from Uniprot.org
