• Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Tris-EDTA, pH9.0 was used for antigen retrieval. 2 Antibody was diluted at 1:200 (4°C overnight. 3, Secondary antibody was diluted at 1:200 (room temperature, 45min).

Anti-FLNC antibody (335-385 aa) (STJ196198)

SKU:
STJ196198

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: IHC/IF
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Filamin-C (335-385 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC-P 1:50-200
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FLNC
Gene ID: 2318
Uniprot ID: FLNC_HUMAN
Immunogen Region: 335-385 aa
Specificity: This antibody detects endogenous levels of FLNC at Human/Mouse
Immunogen: Synthesized peptide derived from the human FLNC at the amino acid range 335-385
Post Translational Modifications Ubiquitinated by FBXL22, leading to proteasomal degradation.
Function Muscle-specific filamin, which plays a central role in sarcomere assembly and organization. Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events.
Protein Name Filamin-C
Fln-C
Flnc
Abp-280-Like Protein
Abp-L
Actin-Binding-Like Protein
Filamin-2
Gamma-Filamin
Database Links Reactome: R-HSA-446353
Cellular Localisation Cytoplasm
Membrane
Peripheral Membrane Protein
Cytoskeleton
Myofibril
Sarcomere
Z Line
A Small Amount Localizes At Membranes
In Striated Muscle Cells
It Predominantly Localizes In Myofibrillar Z Lines
While A Minor Fraction Localizes With Subsarcolemme
Targeting To Developing And Mature Z Lines Is Mediated By The Intradomain Insert
Alternative Antibody Names Anti-Filamin-C antibody
Anti-Fln-C antibody
Anti-Flnc antibody
Anti-Abp-280-Like Protein antibody
Anti-Abp-L antibody
Anti-Actin-Binding-Like Protein antibody
Anti-Filamin-2 antibody
Anti-Gamma-Filamin antibody
Anti-FLNC antibody
Anti-ABPL antibody
Anti-FLN2 antibody

Information sourced from Uniprot.org

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