| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Mitochondrial fission 1 protein (27-77) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FIS1 |
| Gene ID: |
51024 |
| Uniprot ID: |
FIS1_HUMAN |
| Immunogen Region: |
27-77 |
| Specificity: |
This antibody detects endogenous levels of human FIS1 |
| Immunogen: |
Synthesized peptide derived from human FIS1 AA range: 27-77 |
| Function | Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event. Also mediates peroxisomal fission. May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. |
| Protein Name | Mitochondrial Fission 1 ProteinFis1 HomologHfis1Tetratricopeptide Repeat Protein 11Tpr Repeat Protein 11 |
| Database Links | Reactome: R-HSA-9603798 |
| Cellular Localisation | Mitochondrion Outer MembraneSingle-Pass Membrane ProteinPeroxisome Membrane |
| Alternative Antibody Names | Anti-Mitochondrial Fission 1 Protein antibodyAnti-Fis1 Homolog antibodyAnti-Hfis1 antibodyAnti-Tetratricopeptide Repeat Protein 11 antibodyAnti-Tpr Repeat Protein 11 antibodyAnti-FIS1 antibodyAnti-TTC11 antibodyAnti-CGI-135 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
