| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FIP1L1 |
| Gene ID: | 81608 |
| Uniprot ID: | FIP1_HUMAN |
| Immunogen Region: | 1-300 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human FIP1L1 (NP_001128409.1). |
| Immunogen Sequence: | MSAGEVERLVSELSGGTGGD EEEEWLYGDENEVERPEEEN ASANPPSGIEDETAENGVPK PKVTETEDDSDSDSDDDEDD VHVTIGDIKTGAPQYGSYGT APVNLNIKTGGRVYGTTGTK VKGVDLDAPGSINGVPLLEV DLDSFEDKPWRKPGADLSDY FNYGFNEDTWKAYCEKQKRI RMGLEVIPVTSTTNKITAED CTMEVTPGAEIQDGRFNLFK VQQGRTGNSEKETALPSTK |
| Function | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. |
| Protein Name | Pre-Mrna 3'-End-Processing Factor Fip1Hfip1Fip1-Like 1 ProteinFactor Interacting With PapRearranged In Hypereosinophilia |
| Database Links | Reactome: R-HSA-159231Reactome: R-HSA-72187Reactome: R-HSA-72203Reactome: R-HSA-73856Reactome: R-HSA-77595Reactome: R-HSA-9673766 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Pre-Mrna 3'-End-Processing Factor Fip1 antibodyAnti-Hfip1 antibodyAnti-Fip1-Like 1 Protein antibodyAnti-Factor Interacting With Pap antibodyAnti-Rearranged In Hypereosinophilia antibodyAnti-FIP1L1 antibodyAnti-FIP1 antibodyAnti-RHE antibody |
Information sourced from Uniprot.org