| Function | Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E-box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters. |
| Protein Name | Factor In The Germline AlphaFigalphaClass C Basic Helix-Loop-Helix Protein 8Bhlhc8Folliculogenesis-Specific Basic Helix-Loop-Helix ProteinTranscription Factor Figa |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Factor In The Germline Alpha antibodyAnti-Figalpha antibodyAnti-Class C Basic Helix-Loop-Helix Protein 8 antibodyAnti-Bhlhc8 antibodyAnti-Folliculogenesis-Specific Basic Helix-Loop-Helix Protein antibodyAnti-Transcription Factor Figa antibodyAnti-FIGLA antibodyAnti-BHLHC8 antibody |
Information sourced from Uniprot.org
