| Host: |
Goat |
| Applications: |
Pep-ELISA |
| Reactivity: |
Human/Dog/Cow |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-Fibrillin 2 (Internal) is suitable for use in ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
ELISA-antibody detection limit dilution 1:32000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
FBN2 |
| Gene ID: |
2201 |
| Uniprot ID: |
FBN2_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_001990.2 |
| Immunogen Sequence: |
KELKKLEESNEDDC |
| Post Translational Modifications | Placensin: N-glycosylated. O-glycosylated on serine residues by POGLUT2 and POGLUT3. |
| Function | Fibrillin-2: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. Placensin: Hormone secreted by trophoblasts that promotes trophoblast invasiveness. Has glucogenic activity: is able to increase plasma glucose levels. |
| Protein Name | Fibrillin-2 Cleaved Into - Placensin |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-1566948Reactome: R-HSA-2129379 |
| Cellular Localisation | SecretedFibrillin-2 And Placensin Chains Are Still Linked Together During The Secretion From CellsBut Are Subsequently Separated By FurinFibrillin-2: SecretedExtracellular SpaceExtracellular MatrixPlacensin: SecretedSecreted By Placental Cells |
| Alternative Antibody Names | Anti-Fibrillin-2 Cleaved Into - Placensin antibodyAnti-FBN2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
