| Function | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. |
| Protein Name | Fyve - Rhogef And Ph Domain-Containing Protein 5Zinc Finger Fyve Domain-Containing Protein 23 |
| Database Links | Reactome: R-HSA-9013149 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionRuffle MembraneEndoplasmic ReticulumGolgi ApparatusEarly EndosomeIn Peripheral Membrane RufflesColocolizes With F-ActinIn Confluent HuvecsDetected At Cell-Cell-Contact Sites Where It Colocalizes With Vascular Endothelial Cadherin/Cdh5 |
| Alternative Antibody Names | Anti-Fyve - Rhogef And Ph Domain-Containing Protein 5 antibodyAnti-Zinc Finger Fyve Domain-Containing Protein 23 antibodyAnti-FGD5 antibodyAnti-ZFYVE23 antibody |
Information sourced from Uniprot.org
