• Western blot analysis of lysates from COS7 cells, treated with forskolin 40nM 30', using FFAR1 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Immunofluorescence analysis of LOVO cells, using FFAR1 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of COS-7 cells using GPR40 Polyclonal Antibody diluted at 1：500
  • Western blot analysis of Mouse-kidney lysis using GPR40 antibody. Antibody was diluted at 1:500
  • Western blot analysis of COS7 cells using GPR40 Polyclonal Antibody diluted at 1：500

Anti-FFAR1 antibody (185-234 aa) (STJ93384)

SKU:
STJ93384

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IF/ELISA
Reactivity: Human/Monkey
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Free fatty acid receptor 1 (185-234 aa) is suitable for use in Western Blot, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IF 1:200-1:1000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FFAR1
Gene ID: 2864
Uniprot ID: FFAR1_HUMAN
Immunogen Region: 185-234 aa
Specificity: GPR40 Polyclonal Antibody detects endogenous levels of GPR40 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human FFAR1 at the amino acid range 185-234
Function G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis.receptor signaling activates pathways that inhibit osteoclast differentiation. Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation.
Protein Name Free Fatty Acid Receptor 1
G-Protein Coupled Receptor 40
Database Links Reactome: R-HSA-381771
Reactome: R-HSA-400511
Reactome: R-HSA-416476
Reactome: R-HSA-434316
Reactome: R-HSA-444209
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Free Fatty Acid Receptor 1 antibody
Anti-G-Protein Coupled Receptor 40 antibody
Anti-FFAR1 antibody
Anti-GPR40 antibody

Information sourced from Uniprot.org

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