| Host: |
Goat |
| Applications: |
Pep-ELISA/WB/IHC |
| Reactivity: |
Human/Mouse/Rat/Dog |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-FEZ1/Zygin 1 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
Peptide ELISA: antibody detection limit dilution 1:64000.WB: Approx 75kDa band observed in lysates of cell line Kelly, ans in Rat Brain lysates (calculated MW of 45.1kDa according to human NP_005094.1 and 45.2kDa according to Rat NP_112328.1). T |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
FEZ1 |
| Gene ID: |
9638 |
| Uniprot ID: |
FEZ1_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_005094.1 |
| Specificity: |
This antibody is expected to recognize isoform 1 (NP_005094.1) only. |
| Immunogen Sequence: |
QNKQKEQRELMKK |
| Post Translational Modifications | Phosphorylated by protein kinase C zeta.which enhances interaction with UBE4B and polyubiquitination. Polyubiquitinated in a UBE4B-dependent manner.which does not lead to proteasomal degradation and may be important for neurogenic activity. Polyubiquitin linkage seems to be mainly through Lys-26. |
| Function | May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules. |
| Protein Name | Fasciculation And Elongation Protein Zeta-1Zygin IZygin-1 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCell MembraneColocalizes With BothAlpha- And Gamma-TubulinTranslocated From The Plasma Membrane To The Cytoplasm By Activation Of The Pkc Zeta |
| Alternative Antibody Names | Anti-Fasciculation And Elongation Protein Zeta-1 antibodyAnti-Zygin I antibodyAnti-Zygin-1 antibodyAnti-FEZ1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
