| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-FCRL1 (165-177) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:64000.WB: Approx 45 + 40kDa bands observed in Human Heart lysates and 38kDa in Human Liver lysates (calculated MW of 46.9kDa according to NP_443170.1 and of 40.4kDa according to NP_001152869.1). |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | FCRL1 |
| Gene ID: | 115350 |
| Uniprot ID: | FCRL1_HUMAN |
| Immunogen Region: | 165-177 |
| Accession Number: | NP_443170.1; NP_001152869.1; NP_001152870.1 |
| Specificity: | This antibody is expected to recognize all reported isoforms (NP_443170.1; NP_001152869.1; NP_001152870.1). |
| Immunogen Sequence: | TAEYEIPSVRESD |
| Post Translational Modifications | Phosphorylated on tyrosines upon activation. |
| Function | Type I transmembrane surface glycoprotein preferentially expressed by B-cells that regulates BCR-mediated signaling responses. Recruits ABL1 as the intracellular effector molecule to enhance B-cell activation. Plays also a negative role by suppressing ERK activation under homeostatic and BCR-stimulated conditions in a GRB2-dependent manner. |
| Protein Name | Fc Receptor-Like Protein 1Fcr-Like Protein 1Fcrl1Fc Receptor Homolog 1Fcrh1Ifgp Family Protein 1Hifgp1Immune Receptor Translocation-Associated Protein 5Cd Antigen Cd307a |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Fc Receptor-Like Protein 1 antibodyAnti-Fcr-Like Protein 1 antibodyAnti-Fcrl1 antibodyAnti-Fc Receptor Homolog 1 antibodyAnti-Fcrh1 antibodyAnti-Ifgp Family Protein 1 antibodyAnti-Hifgp1 antibodyAnti-Immune Receptor Translocation-Associated Protein 5 antibodyAnti-Cd Antigen Cd307a antibodyAnti-FCRL1 antibodyAnti-FCRH1 antibodyAnti-IFGP1 antibodyAnti-IRTA5 antibody |
Information sourced from Uniprot.org
