| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-F-BAR domain only protein 1 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FCHO1 |
| Gene ID: |
23149 |
| Uniprot ID: |
FCHO1_HUMAN |
| Specificity: |
This antibody detects endogenous levels of FCHO1 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human FCHO1 |
| Function | Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation. Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation. |
| Protein Name | F-Bar Domain Only Protein 1 |
| Database Links | Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
| Cellular Localisation | MembraneClathrin-Coated PitPeripheral Membrane ProteinCytoplasmic SideAssociated With Forming But Not Mature Clathrin-Coated VesiclesThe Recruitment To Coated-Pits Precede The One Of Clathrin And The Adaptor Protein Complex Ap-2It May Also Dynamically Associate With Golgi/Tgn Membranes |
| Alternative Antibody Names | Anti-F-Bar Domain Only Protein 1 antibodyAnti-FCHO1 antibodyAnti-KIAA0290 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
